Bills vs Cardinals Predictions & Odds: Who is Favored in Week 1 Matchup?

Bills Vs Cardinals Odds Overview

👇This table highlights the most important details related to odds and betting for this Week 1 matchup. 

👇It can also be important to know the expected lineups, weather forecast and location details of this week 1 matchup

Comparing the Odds for Bills vs Cardinals

Bills vs Cardinals Injury Report

Who is Favored to Win?

According to Draftkings and other Sportsbooks in Ontario, The Buffalo Bills are 7 point favorites against the Arizona Cardinals in their week 1 matchup. These odds can vary depending on the operator so its important to check odds at different sportsbooks.

Bills Chances To Win vs Cardinals

The Bills have opened up as 6.5-point favorites over the Arizona Cardinals in Week 1. The total is set at 48. With the Cardinals having a healthy Kyler Murray and the No. 4 overall pick Marvin Harrison Jr. having made a slew of terrific catches in training camp, the unknown revolves around the Cardinals' offense. The Bills are rightfully a heavy favorite as they have made the playoffs in five straight years and have reigned over the AFC East in four straight.

How The Bills Win vs Cardinals

The Bills will beat the Cardinals if they expose their ultra-weak secondary. The Arizona Cardinals allowed a 68.58% completion percentage to opposing quarterbacks a season ago which was the second worst in the NFL. Unfortunately for them, the Buffalo Bills have one of the most dynamic quarterbacks in the league in Allen. He did struggle with a career-high 18 interceptions in 2023, so his ability to limit turnovers will be drastically important in winning and covering as well.

How The Cardinals Win vs Bills

Similarly, the Cardinals likely won't be able to tame the Allen-led Bills onslaught, but what they can do is keep pace. Murray threw for 3,971 yards in his second season in the NFL and notched 26 touchdowns. He's battled injuries and is back with the NFL Draft's most dangerous weapon. The Cardinals win if they can get Harrison Jr. going early. The Bills' weakness defensively should be in their secondary, which won't match up well against what should be a pass-heavy Arizona team.

 

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History of Bills vs Cardinals Games

The Cardinals and Bills haven't played many games over the years. With the former being in the NFC West and the latter in the AFC East, they've only paired up in 12 cross-conference matchups. The Bills lead the series 7-5 and have won six of the last eight between the two.

All-Time Best Bills vs Cardinals Games

The last game between these two took place on Nov. 15, 2020. There have only been two games since the end of the 2012 season. The Cardinals won three of the first four but have struggled since. These teams have never met in the playoffs, and without a huge history, this Week 1 showdown could have what it takes to be exciting despite Buffalo being favored.

Game 1: Nov. 15, 2020 - Cardinals 32, Bills 30

Just like their Week 1 game, this one featured Josh Allen and Kyler Murray. Allen had a game-changing two interceptions as the Bills run game never got going. The star did end with 284 yards as the Bills scored in every quarter. The Cardinals offense blew up with 17 points in the third quarter. Murray went for 245 passing yards, and the Cardinals went for over 200 rushing yards. This was a high-energy game between two teams that were, at that time, well above .500.

Game 2: Oct. 14, 2012 - Bills 19, Cardinals 16

While not quite as exciting, this is the lone game of the 12 that has gone to overtime. The Bills had journeyman Ryan Fitzpatrick as their quarterback to start the game while the Bills had Kevin Kolb. The Cardinals were 4-2 at this point but finished the season 5-11, so things took a downward toll after this battle. This battle was one that both teams prioritized the run game with the Bills totaling 165 yards on 33 carries with 2 touchdowns. Arizona ended with 182 rushing yards.

Game 3: Sept. 21, 1986 - Bills 17, Cardinals 10

There aren't too many options to choose from, but this was a game that featured Jim Kelly and was before the Bills blew up into one of the most dominant franchises in the 1990s. Kelly struggled and had just 10 pass attempts for 105 yards. Although it was a run-heavy game, neither team topped 125 yards. This one is mainly here due to the presence of Kelly, and fans getting to experience a team behind a quarterback just years before they blew up.

History of the Bills Vs Cardinals

Below is a history of every time the Bills have matched up against the Cardinals:

The Bills have played the Cardinals a total of 12 times and the Bills lead the series 7-5.

Related Buffalo Bills Betting Content:

Author

Brandon Justice

@BrandonJustice_

Brandon Justice has nearly a decade of experience covering sports and betting, primarily working in college football, college basketball, NFL and MLB. His goal is providing detailed analysis on the trends & data of sports betting with a wealth of experience, including writing for The Action Network & Rivals.com.